Late-Breaking Clinical Trials & Clinical Science

Program Information

Share impactful research to improve the field of interventional cardiology! Present and discuss innovative studies that highlight the latest breakthroughs in science and enhancements to quality patient care and significantly impact the field of interventional cardiology at CRT 2025.

Late-Breaking Trial submissions have closed. Submitters will be notified of acceptance in January.

Recognition

In addition to exposure among colleagues, selected Late-Breaking Trial presenters will become CRT 2025 Associate Faculty. CRT 2025 Associate Faculty receive the following benefits:

Submission Details

CRT 2025 Late-Breaking Trials are expected to contain the study design, baseline characteristics of the patients enrolled, and trial results. Examples of Late-Breaking Trials include primary results from randomized controlled trials; subgroup analyses, post hoc or prespecified, and long-term follow-up results of randomized trials; observational studies of devices or treatments; and meta-analyses of multiple studies.

Submission Deadline

Late-Breaking Trials must be submitted electronically by 5:00 PM ET on Wednesday, January 15, 2025.

Inquiries

If you have any questions, please email submissions@crtmeeting.org.

Late-Breaking Clinical Trials - Coronary 

  • Paclitaxel-Coated Balloon Versus Uncoated Balloon for Coronary In-Stent Restenosis – Two-Year Outcomes of the AGENT IDE Trial 

Jeffrey Moses

  • Real-World Usage of Prevail Paclitaxel-Coated Balloon Compared With Other Contemporary Drug-Coated Balloons – A Two-Year Analysis From the Swedish Coronary Angiography and Angioplasty Registry in Over 6,000 Patients 

Sacharias von Koch

  • Intravascular Lithotripsy or Mechanical Debulking for the Treatment of Complex Calcified Coronary Arteries: The Multicenter, Prospective ROLLING-STONE Trial 

Enrico Cerrato

  • The Impact of the RADPAD Protection Drape in Reducing Radiation Exposure in a Contemporary Cardiac Catheterization Laboratory | The ATTENUATE Trial

Giorgio Medranda

Late-Breaking Clinical Science - Coronary 

  • Drug-Coated Balloons vs Drug-Eluting Stents for the Treatment of Large Native Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials

Jose Antonio Sorolla Romero

  • Sirolimus-Coated Balloon vs Drug-Eluting Stent in Elderly Patients With Coronary Artery Disease: A Propensity-Score Matched Comparison

Filippo Luca Gurgoglione 

  • Institutional Variability in Processes of Care and Outcomes Among Patients With ST-Elevation Myocardial Infarction in the United States: Contemporary Insights From the American Heart Association Get With The Guidelines® – Coronary Artery Disease (GWTG-CAD) Registry 

Yasser Sammour

  • Implementation of a Regional Extracorporeal Membrane Oxygenation Program for Out-of-Hospital Cardiac Arrest: Results of the Pilot Study  

David Shavelle

Late-Breaking Clinical Science - Structural I

  • Evaluating the Safety Profile of Transcatheter Tricuspid Valve Repair: Insights From the TRILUMINATE Pivotal Study of the TriClip System 

Paul Sorajja

  • Transcatheter Aortic Valve Replacement With Self-Expanding Valves vs Balloon-Expandable Valves – A Pooled Analysis From NAVULTRA and NEOPRO2 Registries

Pier Pasquale Leone

  • Evaluating Coronary Access After TAVR With the 4th and 5th-Generation Self-Expanding Valves – The EPROMPT-CA Study

Lior Lupu

  • Supra-Annular vs Intra-Annular Devices for TAVR-in-TAVR: The Pandora International Registry 

Luca Testa

Late-Breaking - Out of the Box Studies

  • Cryotherapy for Vulnerable Plaque Stabilization: Preliminary Report From POLARSTAR, A First-in-Human Study 

Carlos Collet

  • Incremental Prognostic Value of Calcium Detection on the Lipid-Rich Plaque Vulnerability: Development and Validation of an Artificial Intelligence Algorithm For Coronary Calcium Detection With Clinical Follow-Up 

Hector Garcia-Garcia

  • Safety and Efficacy of Renal Stimulation With Direct Wire Pacing Technique During Renal Denervation 

Benjamin Faurie

  • Safety and Efficacy of the Unilateral, Suture-Based, Dry-Closure Technique in Percutaneous Trans-Axillary Aortic Valve Implantation 

Rutger-Jan Nuis

Late-Breaking Clinical Science - Structural II

  • Long-Term Hemodynamic Performance and Clinical Outcomes in Small and Large Aortic Annuli Patients With Severe Aortic Stenosis 

Yasser Sammour 

  • Progression and Outcomes of Mild to Moderate Aortic Stenosis: Insights From the GUARD Prospective Observational Study

Baravan Al-Kassou

  • Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial 

Anastasios Apostolos

Late-Breaking Clinical Science - Coronary II

  • FACT (Fentanyl and Crushed Ticagrelor) PCI: A Randomized Control Trial of Patients Undergoing Percutaneous Coronary Intervention Who Receive Ticagrelor and Fentanyl 

Asna Aafreen

  • Laser Excimer Compared to Very High-Pressure Dilatation to Treat Underexpanded Stents (Laser-Expand Trial) 

Neus Bellera

  • Comparison of Stent Geometry Achieved by Different Side-Branch Ballooning Techniques for Bifurcation Provisional Scenting: The Randomized CRABBIS Trial 

Francesco Burzotta

  • Patient Prosthesis Mismatch and Quality of Life: Data From a Large Multi-Center Registry  

Karim Al-Azizi

Late-Breaking Clinical Trials - Structural & LAA

  • Electrosurgical Leaflet Modification to Prevent Coronary Obstruction During Transcatheter Aortic Valve Replacement in Failing Native and Bioprosthetic Valves: The TELLTALE Trial 

Toby Rogers 

  • Transcatheter Aortic Valve Replacement for Failing Bioprosthetic Surgical Valves: Five-Year Outcomes of the PARTNER 3 Aortic Valve-in-Valve Registry 

S. Malaisrie

  • Outcomes in the ALIGN-AR Continued Access Study for the First Dedicated Transcatheter Aortic Valve for Aortic Regurgitation 

Raj Makkar 

  • Outcomes for Single Antiplatelet, Dual Antiplatelet, or Oral Anticoagulation After Amulet: Insights From Emerge LAA Post-Approval Study 

Atman Shah

Early Feasibility Study - Structural

  • First-in-human Multicenter Experience Using a Novel Sheath Agnostic Radiofrequency Transseptal Wire

Devi Nair

  • Longer-Term Outcomes With AMEND Mitral Annuloplasty: First-in-Human Cohort 

Paul Sorajja

  • Early Results From a TTVR With the Trisol Valve System

Pradeep Yadav

  • Laplace TTVR System: Think Outside the Circle 

Kashish Goel

Late-Breaking Clinical Trial - Endovascular

  • Evaluation of Long-Term Key Outcomes and Safety in Pulmonary Embolism: The EKOS-PE Study 

Sameh Sayfo

  • Large-Bore Mechanical Thrombectomy for Intermediate-Risk Pulmonary Embolism in Patients With Contraindications to Thrombolytics: Outcomes From the Non-Randomized PEERLESS Cohort 

Stefan Stortecky

  • One-Year Outcomes of the Prospective, Multi-Center, Single-Arm Study of the 355-nm Laser for Treatment of Below-the-Knee Arteries: Final Results of the Auryon BTK 

Nicolas Shammas

  • US Pivotal Study of the Vivasure PerQseal System for Large Hole Closure: PATCH

Zvonimir Krajcer

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